Safe- and green-by-design are pre-market design approaches whereby the objectives of minimizing the use of hazardous chemicals, reducing greenhouse gas emissions, and fostering the reuse and recycling of materials in a circular economy are built into product design.
SUSPHARMA fits the European need for sustainable development in modern industry and will develop during the action greener routes to prepare molecules, such as therapeutics and diagnostics.
The project will thus benefit from an interdisciplinary domain, involving:
With its action, SUSPHARMA aims to address different societal challenges of pharmaceutical synthesis, enabling a reduction of the pollution generated during drug manufacturing.
Discover the latest research outcomes from the SusPharma consortium.
Natho, P.; Colella, M.; Luisi, R. Strained spiro heterocycles as potential bioisosteres: an update on the synthesis of heteroatom-containing spiro[2.3]hexanes and spiro[3.3]heptanes. Chemical Communications, 2025. https://doi.org/10.1039/D5CC00656B
Bajada, M. A.; Tschulkow, M.; Vilé, G. Sustainability assessment of single-atom catalysts in the transition to greener chemical processes. Cell Reports Sustainability, 2025. https://doi.org/10.1016/j.crsus.2024.100286
de Vries Ibáñez, M. M.; Cipriano, L. A.; Vilé, G. Photocatalytic C(sp³)–C(sp³) cross-coupling of carboxylic acids and alkyl halides using a nickel complex and carbon nitride. Nature Communications, 2025. https://doi.org/10.1038/s41467-025-61639-8
Graziano, E.; Colella, M.; Luisi, R. Generation and Use of Bicyclo[1.1.0]butyllithium under Continuous Flow Conditions. Organic Letters, 2025. https://doi.org/10.1021/acs.orglett.5c00705
This project has received funding from the European Union – Health and Digital Executive Agency (HADEA) – under the call HORIZON-HLTH-2021-IND-07 – grant agreement No 101057430